Ohankus,

Absolutely.  All you have to do is have the ability to open up a serial (COM) port, set the proper settings (baud rate, start/stop bits, etc), and send/receive commands/responses to/from the Serializer using the Serializer Protocol, which is documented in the Serializer User Guide.

Thus, if you have the ability to open up a COM port within PNtalk/SmallDEVS, then you can certainly control/query everything supported by the Serializer.

I have no experience w/ those languages, so I cannot tell you if there is serial port functionality provided.