For those of you who are attempting to communicate with an I2C device from the Serializer, don't forget we provide the 'Generic I2C Interface'. The interface exists in both the Serializer firmware (see User Guide -> i2c), as well as in the Serializer .NET Library (see Example under Namespace.RoboticsConnection.Serializer.Sensors -> I2CDevice class). So, you can use it from your own custom app, Hyperterm, or from the .NET library.
We added this so that customers wouldn't have to wait on us to add/improve I2C interfaces in the Serializer firmware and/or .NET library. Also, because it's generic, we keep the size of the firmware down. :)